Assistant Professor Sirikalaya Brimson, MT, Ph.D.
ผู้ช่วยศาสตราจารย์ ดร.ทนพญ.ศิริกัลยา บริมสัน
Research Interest
- Drug repurposing for Sigma receptors in cancer cells
- Herbal and plant extracts e.g., flavonoids and related groups effecting leukemia; emphasising on proliferation, apoptosis, autophagy, cell cycle, cell signaling, white blood cell functions
Office
Department of Clinical Microscopy
Tel
+66 2218 1544
sirikalaya.j@chula.ac.th
Links
Research-Specialty-Sirikalaya-1
Education
- Ph.D. (Biochemistry), Virginia Commonwealth University, USA พ.ศ. 2546
- วท.บ. (เทคนิคการแพทย์), จุฬาลงกรณ์มหาวิทยาลัย พ.ศ. 2537
Publications
- Acedera M.L., Sirichokchatchawan W., Brimson S., Prasansuklab A. Age, comorbidities, c-reactive protein and procalcitonin as predictors of severity in confirmed COVID-19 patients in the Philippines(2023) Heliyon, 9 (4), art. no. e15233 DOI: 10.1016/j.heliyon.2023.e15233
- Malar D.S., Thitilertdecha P., Ruckvongacheep K.S., Brimson S., Tencomnao T., Brimson J.M. Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders (2023) CNS Drugs, 37 (5), pp. 399 – 440 DOI: 10.1007/s40263-023-01007-6
- Chomchoei C., Brimson J.M., Brimson S. Repurposing fluoxetine to treat lymphocytic leukemia: Apoptosis induction, sigma-1 receptor upregulation, inhibition of IL-2 cytokine production, and autophagy induction (2022) Expert Opinion on Therapeutic Targets, 26 (12), pp. 1087 – 1097 DOI: 10.1080/14728222.2022.2166829
- Brimson J.M., Brimson S., Prasanth M.I., Thitilertdecha P., Malar D.S., Tencomnao T. The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data (2021) Scientific Reports, 11 (1), art. no. 596 DOI: 10.1038/s41598-020-80045-2
- Brimson J.M., Prasanth M.I., Malar D.S., Brimson S., Thitilertdecha P., Tencomnao T. Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy (2021) Expert Opinion on Therapeutic Targets, 25 (6), pp. 435 – 449 DOI: 10.1080/14728222.2021.1952987
- Brimson J.M., Prasanth M.I., Malar D.S., Brimson S., Tencomnao T. Rhinacanthus nasutus “Tea” infusions and the medicinal benefits of the constituent phytochemicals (2020) Nutrients, 12 (12), no. 3776, pp. 1 – 18 DOI: 10.3390/nu12123776 Brimson J.M., Brimson S., Chomchoei C., Tencomnao T. Using sigma-ligands as part of a multi-receptor approach to target diseases of the brain (2020) Expert Opinion on Therapeutic Targets, 24 (10), pp. 1009 – 1028 DOI: 10.1080/14728222.2020.1805435
- Brimson S., Suwanwong Y., Brimson J.M. Nutritional anemia predominant form of anemia in educated young Thai women (2019) Ethnicity and Health, 24 (4), pp. 405 – 414 DOI: 10.1080/13557858.2017.1346188